HORSE TIMES Magazine :: THE LEADING EQUESTRIAN MAGAZINE IN THE MIDDLE EAST
Add HorseTimes Egypt's Equestrian Magazine to your Favorites Join HorseTimes Egypt's Equestrian Magazine on Facebook Subscribe to HorseTimes Egypt's Equestrian Magazine on Youtube Follow HorseTimes Egypt's Equestrian Magazine on Google+ Pin HorseTimes Egypt's Equestrian Magazine Photos Follow HorseTimes Egypt's Equestrian Magazine Latest News
HOME PROFILE ADVERTISE SUBSCRIBE LINKS CONTACT

The Leading Equestrian Magazine In The Middle East

Welcome To Horse Times
HORSE TIMES is a complimentary quarterly English-language magazine established in Egypt in 1997. It is the only English language publication in the Middle East dedicated to improving access .. read more..

Horse Times Magazine :: Spring Issue # 56

PUBLISHED SPRING 2018, ISSUE 56 FEATURES:

JERASH FRIENDLY INTERNATIONAL CLUB COMPETITIONS 2018
FRIENDLY IN SPIRIT, YET SERIOUS IN PERFORMANCE

LEGAL TIPS
THE “USEF” RULES FOR 2018

EL-GOUNA BEACH POLO
FOUR DAYS OF THRILLING SPORT PLAYED ON THE HEAVENLY RED SEA SHORE

TRAINING TIPS
TH..

VIEW MAGAZINE ISSUES HERE >>

Horse Times Weekly Headlines :: Issue # 31

FEI WORLD CUP JUMPING STAGE IN A CORUÑA
EDWINA TOPS-ALEXANDER IS THE ABSOLUTE WINNER


CASAS NOVAS INTERNATIONAL JUMPING SHOW
SAMEH EL DAHAN FLIES IN THE LONGINES GRAND PRIX


FEI WORLD CUP™ DRESSAGE 2017/2018
WEL SCHNEIDER AND SAMMY SCOOP THE HONORS IN SALZBURG


VAULTERS SPARKLE IN SA..

VIEW HEADLINES ISSUES HERE >>



ALLTECH FEI WORLD EQUESTRIAN GAMES
NORMANDY 2014

Download here >>
NEWS EVENTS HEADLINES ISSUES ARTICLES VIDEOS STREAMING BLOG
HORSE TIMES NEWS DETAILS
>> DEXAMETHASONE IN PREGNANT MARES
Date: Wednesday, March 16, 2016
Horse Times Egypt: Equestrian Magazine :News :DEXAMETHASONE IN PREGNANT MARES

Equine Veterinary Journal Early View February 2016

 

By Heather Ferguson

 

Effects of maternal dexamethasone treatment on pancreatic β cell function in the pregnant mare and post natal foal


 

Valenzuela, O.A., Jellyman, J.K., Allen, V.L., Holdstock, N.B. and Fowden, A.L.

 

To investigate the effects on the metabolism (in particular glucose regulation) of pregnant mares and their offspring,  intramuscular dexamethasone (200 µg/kg bwt) was administered to 6 pregnant mares on 3 occasions at 48 hour intervals. Five pregnant mares were injected at the same intervals with saline. Serial intravenous glucose tolerance tests were performed on all horses, 48 hours before the first dexamethasone/saline treatment, 24 hours after the second treatment, and 72 hours after the final treatment.

 

Baseline plasma concentrations of glucose, insulin and lactate were similar in both treatment and control groups. Within 3 days of treatment commencing, concentrations were significantly higher in the dexamethasone group than in the control group. Post-treatment, there was no difference in glucose or lactate concentrations but plasma insulin remained significantly higher in the treated group. The maximal glucose concentrations following dexamethasone treatment were not significantly different between the two groups; however, the magnitude of the insulin response to glucose was significantly higher in the dexamethasone treated group and the insulin response was more prolonged, indicating a greater pancreatic β cell response to exogenous glucose.

 

All foals were delivered uneventfully and when mature. Femur length and placental area were significantly lower in the dexamethasone treated group compared with the controls. There was no difference in growth rate of foals up to 12 weeks or plasma cortisol concentrations between treatment groups. The foals’ pancreatic β cell response to glucose was unaffected by maternal dexamethasone treatment with no difference between groups; however, there was a difference in the response to arginine, with a significantly lower insulin response in the dexamethasone group foals compared with the control group at 12 weeks old. This suggests maternal dexamethasone treatment suppresses the ability of insulin to stimulate uptake of amino acids.

 

 

Bottom line:

 

Maternal treatment with dexamethasone during pregnancy affects glucose and insulin regulation in the mare, results in lower placental size but does not significantly alter foal growth after birth. It does not significantly alter glucose and insulin metabolism in the foal but does reduce amino acid uptake.

 

 

--Ends--

COMMENTS




Upcoming Events & Coverages



Olympia Horse Show (13-19 December 2016) - EQUIST (19-21 May 2017)

Copyright 2009 - 2018 © Horse Times. All rights reserved. powered by zanss.com